gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tumor cells transduced to express HSV‑enhanced thymidine kinase phosphorylate valganciclovir/ganciclovir to ganciclovir triphosphate, which inhibits DNA synthesis (DNA polymerase/chain elongation), causing death of those transduced cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Phosphorylated by the HSV‑enhanced thymidine kinase expressed from GEN2 in transduced tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06391918
disease_id_num_tar_ref
1111
drug_id_num_tar_ref
3027