gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Allogeneic gamma-delta CAR T cells bind B7-H3 on tumor cells and directly kill them via MHC-independent immune synapse with perforin/granzyme release (with cytokine-mediated effects).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Expressed on glioma tumor cells and tumor-associated vascular endothelium; CAR recognition is MHC-independent
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06018363
disease_id_num_tar_ref
1112
drug_id_num_tar_ref
3029