gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 bnAb binds gp120 on Env-expressing infected cells and recruits FcγR-bearing effector cells (e.g., NK cells, macrophages) to mediate ADCC and antibody-dependent phagocytosis, with possible complement-mediated lysis, thereby killing the target cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Neutralizes virions and blocks entry by binding the CD4-binding site on gp120
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612178
disease_id_num_tar_ref
1120
drug_id_num_tar_ref
3052