gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
3BNC117-LS binds HIV-1 Env on infected cells and engages CD16a on NK cells/monocytes via its Fc to trigger ADCC/phagocytosis, killing the Env-expressing infected cells; CD16a+ effector cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC engagement on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612178
disease_id_num_tar_ref
1120
drug_id_num_tar_ref
3052