gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
3BNC117-LS binds HIV-1 gp120 on infected cells; its Fc engages Fcγ receptors (including CD32a) on effector cells to trigger ADCC/phagocytosis of Env+ targets. CD32a-expressing cells serve as effectors, not killed targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated phagocytosis engagement on myeloid cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612178
disease_id_num_tar_ref
1120
drug_id_num_tar_ref
3052