gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The antibody binds the gp120 V3 N332 supersite on Env displayed by infected cells and engages Fcγ receptors on NK cells/macrophages to trigger ADCC and antibody-dependent phagocytosis, leading to killing/removal of the target cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Glycan-dependent epitope on Env V3 loop
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612178
disease_id_num_tar_ref
1120
drug_id_num_tar_ref
3053