gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
10-1074-LS binds FcRn only to extend antibody half-life via recycling; it does not target or kill FcRn-expressing cells. Any killing by this drug is via Fcγ receptor–mediated ADCC/phagocytosis against HIV Env–expressing infected cells, not FcRn+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc engagement (LS mutations increase affinity; half-life extension)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05612178
disease_id_num_tar_ref
1120
drug_id_num_tar_ref
3053