gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and mediates Fc-dependent killing (ADCC by NK cells, CDC via complement, ADCP by macrophages) and can induce direct apoptosis of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibits CD38 ectoenzyme (NADase/ADP-ribosyl cyclase) activity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922501
disease_id_num_tar_ref
123
drug_id_num_tar_ref
329