gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes/expands neoantigen-specific CD8+ T cells that recognize the neoantigen–HLA I complexes on tumor cells and kill them via CTL cytotoxicity (perforin/granzyme and Fas–FasL–mediated apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ T-cell targets; peptide–HLA class I complexes on melanoma cells/APCs; individualized per patient
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05933577
disease_id_num_tar_ref
1142
drug_id_num_tar_ref
3125