gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes neoantigen‑specific T cells; CD4+ T cells recognizing neoantigen peptides on HLA class II (and supporting CD8+ CTLs) can kill MHC II–positive tumor cells via perforin/granzyme or Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ T-cell targets; peptide–HLA class II complexes on antigen-presenting cells; individualized per patient
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05933577
disease_id_num_tar_ref
1142
drug_id_num_tar_ref
3125