gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
T-DXd binds HER2, is internalized, and releases deruxtecan, which inhibits DNA topoisomerase I to cause DNA damage and apoptosis (with a bystander effect). Topoisomerase I is not the antigen recognized by the drug.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload deruxtecan (DXd) inhibits TOP1 after intracellular release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06085755
disease_id_num_tar_ref
1155
drug_id_num_tar_ref
3153