gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and engages effector functions via its Fc to induce NK cell–mediated ADCC, complement-dependent cytotoxicity (CDC), and macrophage ADCP; it can also trigger apoptosis upon receptor crosslinking.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibits CD38 ectoenzyme (NADase/ADP-ribosyl cyclase) activity; enables Fc-mediated ADCC/CDC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05272826
disease_id_num_tar_ref
1157
drug_id_num_tar_ref
3162