gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Belantamab mafodotin binds BCMA, is internalized, and delivers the MMAF auristatin payload to inhibit tubulin polymerization, causing G2/M arrest and apoptosis; its afucosylated Fc also enhances ADCC/ADCP.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated IgG1 antibody moiety; mediates ADCC/ADCP and enables ADC internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05922501
disease_id_num_tar_ref
123
drug_id_num_tar_ref
330