gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds FOLR1 on target cells, is internalized, and lysosomal cleavage releases the SC209 tubulin polymerization inhibitor, disrupting microtubules and causing mitotic arrest and cell death in FOLR1+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored receptor; antibody binding drives internalization and lysosomal release of payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06555263
disease_id_num_tar_ref
1163
drug_id_num_tar_ref
3182