gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds FOLR1 (not beta-tubulin), is internalized, and releases SC209, which inhibits beta-tubulin polymerization, causing microtubule disruption, mitotic arrest, and death of FOLR1-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload SC209 (3-aminophenyl hemiasterlin) binds the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06555263
disease_id_num_tar_ref
1163
drug_id_num_tar_ref
3182