gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2, is internalized, and releases MMAE in lysosomes; MMAE disrupts microtubules, causing G2/M arrest and apoptosis. The membrane-permeable payload can also cause bystander killing; Fc functions may add ADCC.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antigen; cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06055153
disease_id_num_tar_ref
1174
drug_id_num_tar_ref
3209