gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Disitamab vedotin targets HER2, not beta-tubulin. After HER2-mediated internalization, MMAE is released and inhibits tubulin polymerization, causing G2/M arrest and apoptosis; bystander killing can occur.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload target (MMAE; vinca-binding site on microtubules)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06055153
disease_id_num_tar_ref
1174
drug_id_num_tar_ref
3209