gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds B7-H3 on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload that induces DNA damage, leading to apoptosis and cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Antibody target (tumor-associated antigen)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06008366
disease_id_num_tar_ref
1182
drug_id_num_tar_ref
3233