gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-mesothelin CAR T cells bind mesothelin, activating CD3ΞΆ/4-1BB signaling and inducing T-cell cytotoxicity (perforin/granzyme-mediated apoptosis, possibly Fas/FasL), killing mesothelin+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface mesothelin (GPI-anchored)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05623488
disease_id_num_tar_ref
1187
drug_id_num_tar_ref
3243