gene_symbol
F3
hgnc_id
HGNC:3541
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti–TF ADC binds TF (CD142) on the cell surface, is internalized, and releases MMAE via linker cleavage; MMAE disrupts microtubules, causing G2/M arrest and apoptosis (with possible added Fc-mediated cytotoxicity).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by the IgG1 ADC component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05866354
disease_id_num_tar_ref
1204
drug_id_num_tar_ref
3286