gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets tissue factor (TF) on the cell surface; after TF-mediated internalization, MMAE binds tubulin beta and disrupts microtubules to cause G2/M arrest and apoptosis. Tubulin is not the targeted antigen, so cells expressing only tubulin are not selectively killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the MMAE payload; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05866354
disease_id_num_tar_ref
1204
drug_id_num_tar_ref
3286