gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HBIG binds HBsAg on infected hepatocytes; its Fc engages CD16A (FCGR3A) on NK cells to trigger ADCC that kills HBsAg+ hepatocytes. CD16A-expressing cells act as effectors and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NK-cell Fcγ receptor mediating ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05293158
disease_id_num_tar_ref
1211
drug_id_num_tar_ref
3298