gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HBIG binds HBsAg on infected hepatocytes; its Fc engages CD64 (FCGR1A) on myeloid effectors to trigger ADCC against the hepatocytes. CD64+ cells are effectors, not targets, and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
High-affinity Fcγ receptor on monocytes/macrophages contributing to effector functions
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05293158
disease_id_num_tar_ref
1211
drug_id_num_tar_ref
3298