gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CDR404 binds CD3 on T cells to activate and tether them to MAGE-A4/HLA-A2–positive tumor cells, leading T-cell–mediated killing of the tumor (perforin/granzyme). CD3+ T cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell surface antigen; part of TCR/CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06402201
disease_id_num_tar_ref
1222
drug_id_num_tar_ref
3320