gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific ADC binds EGFR on tumor cells, is internalized, and releases a camptothecin/topoisomerase I–inhibitor payload that induces DNA damage leading to cell death (with potential bystander effect).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; ADC internalization trigger
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05924841
disease_id_num_tar_ref
1223
drug_id_num_tar_ref
3321