gene_symbol
FCER2
hgnc_id
HGNC:3612
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MOv18 IgE binds FRα on tumor cells and engages Fcε receptors (FcεRI/CD23) on immune effector cells to trigger ADCC/ADCP and degranulation that kill FRα+ tumor cells; CD23-expressing cells are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent binding via IgE Fc on B cells and antigen-presenting cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06547840
disease_id_num_tar_ref
1230
drug_id_num_tar_ref
3332