gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 and kill target cells via MHC-independent T-cell activation with perforin/granzyme-mediated cytotoxicity (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MHC-independent recognition of extracellular CD19 epitope on B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06352242
disease_id_num_tar_ref
1237
drug_id_num_tar_ref
3353