gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CD38 on target cells and induces NK cell–mediated ADCC via FcγR, complement-dependent cytotoxicity (CDC), macrophage phagocytosis (ADCP), and can trigger direct apoptosis upon crosslinking.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (NADase/cyclase) on plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05486481
disease_id_num_tar_ref
1239
drug_id_num_tar_ref
3358