gene_symbol
CCR4
hgnc_id
HGNC:1605
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CCR4 IgG1 binds CCR4 on target cells and engages Fc-gamma RIIIa on NK/effector cells to trigger ADCC, leading to lysis/depletion of CCR4-positive malignant T cells and Tregs.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
also known as CD194
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06235281
disease_id_num_tar_ref
1244
drug_id_num_tar_ref
3369