gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets HER2 (not TOP1) for binding and internalization; once inside HER2+ cells, the released deruxtecan inhibits TOP1, causing DNA damage and apoptosis (with possible ADCC and bystander effects).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload target (Topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06533826
disease_id_num_tar_ref
1247
drug_id_num_tar_ref
3380