gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP2 on target cells, is internalized, and releases the DXd topoisomerase I inhibitor after lysosomal linker cleavage, causing DNA damage and apoptosis (with a membrane-permeable payload that can also cause a bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface ADC antigen; internalization enables lysosomal DXd release
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06533826
disease_id_num_tar_ref
1247
drug_id_num_tar_ref
3381