gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind mesothelin on target cells and induce killing via perforin/granzyme-mediated cytolysis and Fas–FasL apoptosis after CAR signaling.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein overexpressed on certain tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06515626
disease_id_num_tar_ref
1252
drug_id_num_tar_ref
3388