gene_symbol
MICA
hgnc_id
HGNC:7090
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
NKG2D-CAR T cells bind MICA on target cells, triggering CD3ζ/costimulatory signaling and releasing perforin/granzymes to induce cytolysis/apoptosis of the bound cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D stress ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06515626
disease_id_num_tar_ref
1252
drug_id_num_tar_ref
3393