gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2, is internalized, and releases a deruxtecan Top1 inhibitor payload causing DNA damage and apoptosis; also induces ADCC and bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC antibody target on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05765851
disease_id_num_tar_ref
1253
drug_id_num_tar_ref
3395