gene_symbol
CD247
hgnc_id
HGNC:1677
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 zeta is the intracellular signaling domain of the CAR in the engineered T/CIK cells and is not a target antigen. CARCIK-CD19 cells bind CD19 on B cells and kill CD19+ cells via perforin/granzyme after CAR signaling through CD3 zeta.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular CAR activation/signaling domain (not an external binding target)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05869279
disease_id_num_tar_ref
1265
drug_id_num_tar_ref
3421