gene_symbol
CD28
hgnc_id
HGNC:1653
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD28 is a costimulatory domain within the CAR T/CIK cells, not the targeted antigen. The therapy kills CD19+ cells via CAR engagement and perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular CAR costimulatory domain (not an external binding target)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05869279
disease_id_num_tar_ref
1265
drug_id_num_tar_ref
3421