gene_symbol
IL2RA
hgnc_id
HGNC:6008
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD25 mAb binds CD25 on target cells and recruits FcγR-bearing effector cells to mediate ADCC (and potentially ADCP/CDC), depleting CD25+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Targets CD25 on regulatory T cells; can mediate ADCC via Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05650242
disease_id_num_tar_ref
1270
drug_id_num_tar_ref
3430