gene_symbol
MUC16
hgnc_id
HGNC:15582
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 antibody binds CA125 (MUC16) on tumor cells and engages Fc effector functions to mediate NK-cell ADCC and complement-dependent cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both tumor-associated and shed circulating CA125
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05605535
disease_id_num_tar_ref
1281
drug_id_num_tar_ref
3474