gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Oregovomab binds CA125 on tumor cells; Fc gamma receptor IIa (CD32a)-expressing immune cells engage its Fc to mediate ADCC/complement/phagocytosis against CA125+ tumor cells, not against CD32a+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent engagement enhances immune complex uptake by dendritic cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05605535
disease_id_num_tar_ref
1281
drug_id_num_tar_ref
3474