gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD22 ADC binds CD22, is internalized, and releases calicheamicin inside the cell, which binds the DNA minor groove to cause double-strand breaks and apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen; antibody binding triggers internalization of the ADC.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05303792
disease_id_num_tar_ref
1284
drug_id_num_tar_ref
3485