gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD38 IgG1 binds CD38 on target cells and recruits Fc-mediated effectors—NK-cell ADCC, complement-dependent cytotoxicity (CDC), and macrophage ADCP—and can trigger apoptosis, leading to depletion of CD38+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane glycoprotein and ectoenzyme (NAD+ nucleosidase/ADP-ribosyl cyclase) on plasma cells and other immune cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06685757
disease_id_num_tar_ref
1289
drug_id_num_tar_ref
3501