gene_symbol
WT1
hgnc_id
HGNC:12796
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous T cells recognize WT1-derived peptides presented on HLA via their native TCRs and directly lyse target cells through perforin/granzyme-mediated cytotoxicity (with CD4+ helper support).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized as peptide-HLA complex (class I/II) by native TCRs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05798897
disease_id_num_tar_ref
1292
drug_id_num_tar_ref
3507