gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused autologous T cells use native TCRs to recognize HLA-presented MAGE-A4 peptides on target cells, triggering cytotoxic T-lymphocyte killing via perforin/granzyme (with possible Fas–FasL) and helper cytokine support.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Recognized as peptide-HLA complex (class I/II) by native TCRs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05798897
disease_id_num_tar_ref
1292
drug_id_num_tar_ref
3507