gene_symbol
TERT
hgnc_id
HGNC:11730
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Oncolytic adenovirus uses the hTERT promoter to drive E1A/E1B, enabling selective viral replication in telomerase-positive cells, causing lytic cell death (oncolysis).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Promoter-driven selectivity: hTERT promoter controls viral E1A/E1B expression, enabling replication in telomerase-positive tumor cells.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06340711
disease_id_num_tar_ref
1296
drug_id_num_tar_ref
3515