gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific ADC binds TROP2 (and EGFR) on tumor cells, is internalized, and releases MMAE via protease cleavage; MMAE inhibits tubulin polymerization, causing G2/M arrest and apoptosis in TROP2/EGFR–coexpressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen; bispecific ADC co-engagement with EGFR; receptor-mediated internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06475937
disease_id_num_tar_ref
1304
drug_id_num_tar_ref
3532