gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
DM001 binds TROP2/EGFR on tumor cells, is internalized, and releases MMAE; MMAE binds beta-tubulin, blocks microtubule polymerization, causing G2/M arrest and apoptosis in the targeted cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds β-tubulin (vinca site) to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06475937
disease_id_num_tar_ref
1304
drug_id_num_tar_ref
3532