gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells bind CLDN18.2 on target cells, triggering T‑cell activation and cytolytic killing via perforin/granzyme release and/or Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
isoform 2-specific of CLDN18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06084286
disease_id_num_tar_ref
1308
drug_id_num_tar_ref
3540