gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 and, upon activation via CD28/CD3ζ signaling, kill CD19+ cells through T cell cytotoxic mechanisms (perforin/granzyme and Fas–FasL), with cytokine release.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain epitope on CD19; FMC63-derived scFv; HLA-independent recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05807789
disease_id_num_tar_ref
1309
drug_id_num_tar_ref
3542