gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AFM13 engages CD16A on NK cells to bridge them to CD30+ tumor cells, activating NK-mediated ADCC and cytotoxic granule release that kills the CD30+ targets; CD16A+ cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NK cell Fc receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05883449
disease_id_num_tar_ref
1311
drug_id_num_tar_ref
3548