gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Zanidatamab binds HER2 ECD2/ECD4 and recruits FcγR-bearing immune cells to mediate ADCC and ADCP, killing HER2-expressing cells (with additional receptor internalization/downregulation).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Domain 2 epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06282575
disease_id_num_tar_ref
1312
drug_id_num_tar_ref
3553